Project: Dinucleoside polyphosphate RNA caps in mammalian cells (2 years) , IOCB Prague
Description
The young international group of Dr. Hana Cahova (https://www.cahovagroup.com/), located in Prague at the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB), is looking for young talented and highly motivated postdoctoral fellows to join our team in a project financed by the ERC CZ program. The position is available immediately. In general, the goal of Dr. Cahova research is an in-depth study of the chemical structure of RNA molecules (both coding and non-coding) and the role, biogenesis, and biodegradation of these RNA structures.
The IOCB is one of the best research institutes in central Europe with excellent equipment and core facilities located in new or reconstructed buildings close to the city center.
The successful candidate will have the opportunity to work on the project focused on the search for new RNA caps in eukaryotic cells. Recently, we have discovered a brand new class of 5’ RNA caps, based on the dinucleoside polyphosphate structure, in bacteria. This postdoctoral project will be focused on dinucleoside polyphosphate capped RNA in mammalian cell lines with respect to tumorigenesis. After the detection of new RNA caps, new chemical or chemo-enzymatic methods will be employed or developed to identify modified RNA sequences. Once the function of modified RNA has been elucidated, the biogenesis, biodegradation, and mechanisms of interaction of RNA with host cell targets will be the objective of further studies.
Candidate requirements
All the applicants should send their CV with a list of publications, motivation letter and contact details of 2-3 referees to Dr. Hana Cahová (cahova@uochb.cas.cz) with subject POSTDOC_HC_2020.
Selected relevant publications:
Hudecek O., Benoni R. et al Nature Comm. 2020 (accepted)
Cahova H. et al. Nature, 519, 374-377, 2015