---
title: Research - Cahová Group
description: Hana Cahová's group studies novel RNA modifications, in particular a new class of RNA caps discovered in bacteria and mammalian cells.
url: "https://www.cahovagroup.com/research"
type: static
generatedAt: "2026-10-07T13:32:51.409Z"
---

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Hana Cahova’s research group focuses on novel RNA modifications, particularly RNA caps. They have discovered a new class of RNA caps based on the structure of dinucleoside polyphosphates in both bacteria and mammalian cells. To investigate these non-canonical RNA caps, they employ advanced LC-MS techniques and develop their own RNA sequencing methods for their identification. Their research explores the biosynthesis, biogenesis, and functional roles of these RNA caps across various model systems, including bacteria and mammalian tissue cell cultures. Additionally, they use a range of molecular biology approaches and collaborate with structural biologists, utilizing cryo-EM to uncover the properties of non-canonically capped RNA.